9/19/2023 0 Comments Mancova gpower![]() Schizophrenia is a devastating mental disorder, characterized by heterogeneous positive and negative symptoms (such as hallucinations, delusions, and reduced expression of emotions or motivation), and cognitive dysfunction (such as difficulties with concentration, working memory, and decision making) ( 1). COMT Val158Met (rs4680) polymorphism inconsistently mediated the relationship between sex and cognitive performance in schizophrenia patients.Ĭonclusion: These findings suggest that COMT Val158Met (rs4680) polymorphism is associated with the risk and severity of schizophrenia in a sexually dimorphic way and contributes more to the clinical symptoms and cognitive impairment in male patients with schizophrenia. Results: We find that male patients had a significantly higher proportion of carrying the Val allele and Val/Val carriers exhibited more severe positive symptoms and cognitive impairment than Met carriers. The psychopathological symptoms of the patients were assessed by the Positive and Negative Syndrome Scale (PANSS). The cognitive performance was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the COMT Val158Met (rs4680) polymorphism is genotyped. Materials and methods: We recruited 367 in patients with chronic schizophrenia (246 males and 121 females) and 419 healthy controls (172 males and 247 females). Thus, this study aims to explore whether there is an effect of the interaction between COMT Val158Met (rs4680) polymorphism and sex on patients’ clinical characteristics and cognitive function. Recent studies show that the influence of COMT Val158Met (rs4680) variation is sexually dimorphic. However, the underlying genetic reasons remain unelucidated. Sex differences have been reported in various aspects of the disease. Objective: Schizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits.
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